Letter: The 'grey toddler': chloramphenicol toxicity.

The 'grey toddler'. Chloramphenicol toxicity.

Fatal aplastic anemia following apparent "dose-related" chloramphenicol toxicity.

T H E R E C O o N I T ! O N of ampicillin-resistant Hemophilus influenzae ~ has increased the use of chloramphenicol, particularly in management of invasive infections caused by this bacterium. Bone marrow toxicity, however, is a serious hazard. Based primarily on clinical data, two different bone marrow toxicities have been proposed. Reversible bone marrow suppression is frequent and dose rela...

Chloramphenicol toxicity in neonates: its incidence and prevention.

The incidence of dose related chloramphenicol toxicity was determined in 64 neonates from 12 hospitals. Ten of the 64 exhibited symptoms attributed clinically to chloramphenicol toxicity. Nine received the dose prescribed and one an overdose. Symptoms of the grey baby syndrome were observed in five of the 10 babies; four babies suffered reversible haematological reactions; and one baby was desc...

Changes in iron metabolism in early chloramphenicol toxicity.

The frequency of hematopoietic depression occurring as a result of chloramphenicol toxicity is not known. Generally it is assumed that the incidence is low in relation to the total amount of chloramphenicol used (1). The deleterious action of chloramphenicol has been noted in all degrees of severity from fatal aplastic anemia (2-6), to minimal marrow depression readily reversible upon removal o...

LETTER TO THE EDITOR On the Mechanism of Nitriles Toxicity

This is apropos to some issues raised by Llorens et al. (2009) on our recent publication unraveling the mode of toxicities of acrylonitrile (ACN) and iminodipropionitrile (IDPN) in rats (Khan et al., 2009). In the following text, we have attempted to provide point-wise explanations to the queries of Llorens et al. in the light of relevant literature. The transient behavioral effects appeared af...